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Hydroxyurea And Increase In RDW (red Cell Distribution Width)

Hydroxyurea And Increase In RDW (red Cell Distribution Width)

I have ET and I’ve been on hydroxurea (1000 mg per day) since Mid-June of 2021 and just got my first monthly blood analysis results. My platelets have dropped from over 850+ down to 451 (still above normal, but a dramatic drop for me!) Everything else looks good except now my RDW (red cell distribution width) number is high - I jumped from 13 to 15.4! It appears that this may be a side effect of hydroxyurea, and I may need to increase my vitamin B-12 intake to see if it helps to reduce it …or… read more

A myMPNteam Member said:

I had a small increase and my Doctor said that's how they know I am taking the Hydroxy. So there must be an affect. Going for blood work every three months.

posted 2 months ago
A myMPNteam Member said:

Thanks for your perspective, Barbara. (I think brain fog might be my new normal-haha!) But seriously, my MD believes my iron levels are currently ok, but suggested I take a women’s regular daily multivitamin to boost my B12 & D intake. He will include a review of a handful of vitamin levels plus FE at my next blood analysis to confirm any deficiencies.

posted about 2 months ago
A myMPNteam Member said:

I have PV and my Red Cell Distribution Width (RDW) has been high for several years. I do not take HU, yet, just phlebotomy. However, when I had iron studies and a bone marrow done summer 2020, they found my iron and Ferritin low and iron stores in BM depleted. I have been on iron since then and RDW is coming down. I have read that low iron can cause brain fog, too. Hope this info helps.

posted about 2 months ago
A myMPNteam Member said:

I'd ask your doc. My RDW has been high ranging from 16%--24.6% My JAK2 V617F were confirmed from blood draw on 7/11/2019; and because of other lab results from that draw was then put on HU and Aspirin. So my RDW was high prior to ever going on HU.

posted 2 months ago
A myMPNteam Member said:

My hematology oncologist is aware and watchful. Told me that’s why I have monthly bloodwork and he sees me every 3 months.

posted 2 months ago
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