I suspect it's the hydroxyurea dose. I had to stop taking it because of skin ulcer side effects, and do feel a bit less fatigued. Now relying on aspirin until am able to see a specialist. RBC keeps dropping far below normal range, however, and my hemo unconcerned. That I don't understand, so looking for better advice.

Hi, I also have ET with a lot of fatigue, I was on 2 per day and my platelets were still in700-800 so hemo increased to 3 per day…. A lot more fatigue, so he told me to take 2 per day and 2 anagrelide per day….fatigue is no better and I feel shaky… so I don’t know what to do either.