I take 2 capsules (500 mg each) mid day since I also take Eliquis morning and night and like to space my medications apart.

I've been on hydra now for 6 yrs at 1,500 mg with 325 mg aspirin and Xarelto 25mg i take all at once every evening and have never been told to take them separately and I'm extremely tired most days

(Im76 yr )Been taking hydra now for 11yr ( 500 mg ) HEMATOLGIST raised my dose to 1000 mg so now I take 1 capsule in morning and 1 at night, and aspirin in morning also just started taking gabapentin (100 mg ) when I go to bed ( for nerve pain ,burning in feet and toes , ( neuropathy)

My Hydroxyurea is a capsule. You must be on a brand name.

Thanks Janet and MH for your input!