Overt Myelofibrosis, grade 2 fibrosis with 30% cellularity, and splenomegaly 21cm. CALR1+, with ASXL1, and TET2 mutations. Blasts only at 2% which is good but that's an increase nonetheless. LDH 800's, RBCs <4.00, HGB 11.5. PLTS 600, slight lymphocyte elevation. nRBC's 10 with polychromatic cells, darcocytes, and ringed cells. Bone scans show "Diffuse osteosclerosis" and I don't know if that means advanced fibrosis or if that's just super common with us MF people.
Symptoms are fatigue, pain in⦠read more