Smoking it or anything will always be negative and create health issues whether an MPN or not.

However, the use of CBD and related oils, etc. are a different story as they in general often provide various health benefits for most ppl MPN or not bc the human body fascinatingly actually has innate built in CBD receptors.

So when given CBD they fit right in like an appropriate puzzle piece.

As with most things all usually depends on the specific person as each has various states of health, diet, meds, Rx, etc.

Best advice is to see a legit certified Functional Med Dr.