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Real members of myMPNteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
October 1, 2025
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Weight changes can occur with MPNs and their treatments. While Jakavi (ruxolitinib) commonly causes side effects in up to 1 in 5 people who take it, the most frequently reported side effect is actually anemia rather than weight gain.

If you're experiencing unexpected weight changes while on Jakavi, it's important to Show Full Answer

Weight changes can occur with MPNs and their treatments. While Jakavi (ruxolitinib) commonly causes side effects in up to 1 in 5 people who take it, the most frequently reported side effect is actually anemia rather than weight gain.

If you're experiencing unexpected weight changes while on Jakavi, it's important to discuss this with your healthcare provider. They can evaluate if the weight gain is related to the medication or if there might be other factors involved. Weight patterns can vary depending on which type of MPN you have. For example, people with ET and PV tend to be more likely to experience weight gain, while those with myelofibrosis often experience unintended weight loss. Your doctor can help determine if your weight changes are related to your specific MPN type, your medication, or other factors that should be addressed.

October 1, 2025

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