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Real members of myMPNteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myMPNteam Member asked a question 💭
Cape Coral, FL
November 30, 2025
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Can bloating occur with essential thrombocythemia (ET) while taking Hydrea (hydroxyurea)?

Bloating isn't typically listed as a direct symptom of ET itself. However, if you have an enlarged spleen (splenomegaly), which can occur with MPNs, this can compress your stomach and cause bloating and a feeling of fullness. The Show Full Answer

Can bloating occur with essential thrombocythemia (ET) while taking Hydrea (hydroxyurea)?

Bloating isn't typically listed as a direct symptom of ET itself. However, if you have an enlarged spleen (splenomegaly), which can occur with MPNs, this can compress your stomach and cause bloating and a feeling of fullness. The enlarged spleen is usually the source of abdominal discomfort directly related to MPNs.

Regarding Hydrea specifically, the common gastrointestinal side effects include:
- Diarrhea
- Constipation
- Upset stomach or nausea

While bloating isn't commonly mentioned as a side effect of Hydrea, digestive issues like these can sometimes lead to bloating. Some myMPNteam members have found that taking Hydrea with food or before bed helps reduce stomach upset.

It's important to discuss your bloating with your healthcare provider, as abdominal discomfort can have various causes - both related and unrelated to your MPN. They can help determine the specific cause and recommend appropriate treatment.

November 30, 2025

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