Has anyone had a glass of wine after being diagnosed with ET/CALR mutation?
January 30
What's the difference between essential thrombocythemia (ET) with a CALR mutation and polycythemia vera (PV)?
The main difference lies in which blood cells are overproduced and the genetic mutations involved.
Essential Thrombocythemia (ET) with CALR mutation
- Causes too many platelets to be produced
- CALR gene Show Full Answer
What's the difference between essential thrombocythemia (ET) with a CALR mutation and polycythemia vera (PV)?
The main difference lies in which blood cells are overproduced and the genetic mutations involved.
Essential Thrombocythemia (ET) with CALR mutation:
- Causes too many platelets to be produced
- CALR gene mutations occur in some ET cases (along with JAK2 or MPL mutations)
- Leads to abnormal blood clotting and blockages in blood vessels
- May also cause excessive bleeding
- More common in women, usually diagnosed between ages 50-70
Polycythemia Vera (PV):
- Causes too many red blood cells (and sometimes white blood cells and platelets)
- Almost always involves a JAK2 gene mutation (specifically JAK2V617F in about 95% of cases)
- The abnormal cells are especially sensitive to erythropoietin (EPO), a hormone that increases red blood cell production
- Also leads to blood clot formation and similar complications
Both conditions can cause serious complications like heart attack, stroke, deep vein thrombosis, and pulmonary embolism due to blood clots. However, they're distinguished by which blood cells are primarily affected and their specific genetic profiles.
January 28
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