Hydroxyurea is a commonly used treatment for ET, and while it's generally well-tolerated, it can cause a range of side effects — some of which can overlap with or resemble autoimmune-type symptoms.
Here are some known side effects of hydroxyurea that may feel autoimmune-like:
- Skin changes — darkened skin, skin ulcers Show Full Answer
Hydroxyurea is a commonly used treatment for ET, and while it's generally well-tolerated, it can cause a range of side effects — some of which can overlap with or resemble autoimmune-type symptoms.
Here are some known side effects of hydroxyurea that may feel autoimmune-like:
- Skin changes — darkened skin, skin ulcers (especially on the ankles or legs), and mouth sores
- Low blood cell counts — which can lead to anemia, increased infection risk, and easy bruising or bleeding
- Digestive issues — nausea, diarrhea, or constipation
- Increased skin cancer risk — sun protection is strongly recommended People with ET are also already at a higher risk of developing autoimmune conditions independently of their treatment. So it can sometimes be tricky to know whether symptoms are a side effect of hydroxyurea or part of the broader MPN picture.
One myMPNteam member shared that hydroxyurea caused them to become anemic, which ultimately required blood transfusions — a good reminder that side effects can sometimes be serious.
It's always worth flagging any new or worsening symptoms to a hematologist promptly. Never stop taking hydroxyurea without speaking to a doctor first, as managing ET effectively is important for reducing clotting risks.
May 18
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