Not sure it can be generalized. My hematologist said the risk of progressing is relatively low, but possible.This article shows the percentage risk is low:

https://pubmed.ncbi.nlm.nih.gov/27579252/

Risk of second primary malignancies in a population-based study of adult patients with essential thrombocythemia - PubMed

https://pubmed.ncbi.nlm.nih.gov/27579252/

I’m afraid I don’t know. I was told that it is very rare, but could happen. That possibility is the major thing that makes me be very consistent with following my treatment regime, regularly keeping my hematologist appointments, and living each day as a blessing.

Thanks. I read the study synopsis, and it’s reassuring. I hope they do a study with a larger base. I bet that’s hard to do, since we’re rare.