I started on 500 mg/day HU in 2022, but dropped my counts too low so stopped. Ii restarted in March with every other day. It seems to have brought my numbers down gradually. I was having phlebotomy every month, but did not need it the last two months. I do have moderate fatigue with SOB, but I am iron deficient. I’m not sure how long it might take to bring up my iron level. I am being considered for the Rusfertide clinical trial which is supposed to regulate your iron and Hct levels.

I highly recommend asking about besremi- it's newer and doctors are less familiar with it. It's the only drug that has shown possibility of remission for PV. I've been on it for almost a year with no side effects and I'm now up to 4 months without phlebotomy.

I started with 500 hydroxy daily , took for 3 weeks then became ill with fevers , weakness , fatigue was hospitalized , all my blood counts dropped meds were stopped , had bone marrow biopsy confirmed PV No leukemia, still very fatigued and short of breath doctors doesnot believe related to PV I am shocked told me to see my family🤪🤪doctor nothing more he can do , also maybe see pulmonologist, I had to restart the hydroxy on a every other day basis just started yesterday, I’m wondering has anyone else had to do this, Best to you with your next step !