Myelodysplastic Syndrome is a different class of blood cancers than Myeloproliferative Neoplasms. There is a phenomena of MDS/MPN overlap, where features of both are present.

I and several other people on here have MDS and MPN and JAK2 mutation as well as other mutations. Leukemia is what we’ve been trying to avoid with treatment. Some have less or more of a propensity to transition depending on mutations and features. I was told 15 years ago that the MDS I had doesn’t usually transition to leukemia. MPN came later. They are all constantly changing. No way to predict where things will go next.

We both have had a Jak 2 mutation. Might be the only overlap?