I saw a different hematologist/oncologist in February and March this year, while traveling in the southeast, and they specifically asked about whether my children and other family members were JAK2 positive and/or had an MPN.

Information gathering, is how I took it.

It is quite common to have acquired the MPN long before it is diagnosed. Sometimes you can get an idea of how long this was by a historic review of your CBCs. Note that there is a difference in acquiring the driver mutation and having the disease process manifest. The JAK2 mutation is often acquired in early childhood, sometime in utero. There is a very sophisticated genetic assessment that can determine this that is used in research settings. It also worth noting that some people are positive for the JAk2 mutation but never manifest a MPN. This condition is referred to as Clonal Hematopoiesis of Inderdetmiant Potential (CHIP). People with CHIP do not have a MPN but do have elevated cardiovascular risks. The trigger for the underlying mutation to manifest as a MPN is being researched. It seems likely that it is a combination of aging, genetic and environmental factors.

https://mpn-hub.com/medical-information/whole-g...
https://www.biorxiv.org/content/10.1101/2020.11...
https://www.sanger.ac.uk/news_item/adult-blood-...

https://www.medscape.com/viewarticle/chip-silen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86...

CHIP: The Silent Threat Steps Into the Limelight

https://www.medscape.com/viewarticle/chip-silent-threat-steps-limelight-2024a1000591?240325&src=FYE&ecd=WNL_recnlnew1_broad_US_perso_etid6399303&uac=295706DK&impID=6399303

Adult blood cancer-causing mutations occur in early childhood  

https://www.sanger.ac.uk/news_item/adult-blood-cancer-causing-mutations-occur-in-early-childhood/

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution

https://www.biorxiv.org/content/10.1101/2020.11.09.374710v1.full

Clonal Hematopoiesis of Indeterminate Potential (CHIP): Linking Somatic Mutations, Hematopoiesis, Chronic Inflammation and Cardiovascular Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629838/

The "why" question is broken into two parts. Why did I develop the JAK2 mutation? Why did the JAK2 mutation manifest as a MPN? There is evidence that that MPNs can cluster in families, called Familial MPNs. One factor in this appears to be the JAK2 46/1 predisposing haplotype, which can be inherited. It is much more complex than this, however. How the JAK2 mutation ultimately manifests in a specific MPN is driven by an array of other factors. There is active research into this issue, including this recent paper.
https://www.nature.com/articles/s41588-023-01638-x

Steve, good info. I am curious about when I acquired the Jak2 mutation. I was diagnosed when I was 46 years old. I'm now 63 years old. My sister, who is one year older than me, has the Jak2 mutation but does not have an MPN. So, she has CHIP. Why did I get this stupid disease....had a slightly high platelet count when I was 40 years old. I hope my sister does not get an MPN.

I believe I was developing ET for years, but donating blood regularly was keeping counts under control, until it didn’t, and I’ve read others accounts of the same kind of thing.

I’ve not heard of anything that can determine exactly when we acquire our MPN’s.