My platelets bounce between 600 and 700 and I have only taken a baby aspirin since 2008. I'm 72 and healthy.

Most docs use 60 as the point where someone is considered high risk. Some use 65. Others do not use age at all, taking a more individualized approach. I prefer that approach as we all age differently. The age-based risk factor does apply to most people with MPNs, but not to all. It is an individual choice we each need to make.,

I agree 100% as i have mentioned before Mark, I am now 72 and only take daily aspirin.
My Hematologist said on last visit he is happy with this regime. Probably for the rest of my life. Originally I was told hydroxy ant 65 here in NZ but that was back in 2015.
I am very happy.
Have just read how interferon/ Pegasys is causing problems with the heart. Some meds are good for one part of the body but bad for another. Not a win win situation.

most of the time baby aspirin is enough in the first years
there is no need for other meds
but visit a Hematologist to look if blood values are stable is what i also did

I was diagnosed with PV at 61. I started out on aspirin and phlebotomy because I didn’t want to take meds if I could avoid. I had a hard time keeping my Hct under 45%, with phlebotomy monthly. This resulted in iron deficiency and with superficial phlebitis and eventually a deep vein thrombosis. I started on HU, but had GI issues. I started on Besremi about 6 months ago. We had to work with finding the right dosage because of anemia, but think we have found the correct dose now. Numbers look good and I am feeling better. No phlebotomy! We all have to find what works best for each of us.