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Real members of myMPNteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Does Anyone Know If There's A Link Between HLA B-27 And JAK2? I've Tested Positive For Both.

A myMPNteam Member asked a question 💭
Durban, ZA

I have ET, arthritis and fibromyalgia.

September 20
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A myMPNteam Member

From what I could find in the scientific literature, there is an association between autoimmune diseases and myeloproliferative neoplasms. People who have an autoimmune disease are more likely to develop an MPN during their lifetime. Chronic inflammation and changes in immunity seem to be part of both groups of diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77...
https://onlinelibrary.wiley.com/doi/full/10.111...

Some of their mechanisms might overlap, sometimes similar genetic mutations might increase the likelihood for either an autoimmune disease or an MPN.
https://www.clinexprheumatol.org/article.asp?a=...
https://www.sciencedirect.com/science/article/a...

This is a Google Scholar search with plenty of studies that could offer an answer to your question regarding this overlap between autoimmunity and for MPNs:
https://scholar.google.se/scholar?q=chronic+inf...

Many hugs of support 🤗

https://www.sciencedirect.com/science/article/abs/pii/S1521661610005802
https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17850
Autoimmunity and the risk of myeloproliferative neoplasms
Autoimmunity and the risk of myeloproliferative neoplasms
KEY ROLE OF INFLAMMATION IN MYELOPROLIFERATIVE NEOPLASMS: INSTIGATOR OF DISEASE INITIATION, PROGRESSION. AND SYMPTOMS
KEY ROLE OF INFLAMMATION IN MYELOPROLIFERATIVE NEOPLASMS: INSTIGATOR OF DISEASE INITIATION, PROGRESSION. AND SYMPTOMS
Google Scholar
September 20
A myMPNteam Member

Thanks a lot! This is very interesting.

September 21

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