myMPNteam

Yes, polycythemia vera (PV) can progress to myelofibrosis (MF). About 25% of people with PV develop myelofibrosis within 20 years of their initial diagnosis.

In this progression, the bone marrow becomes damaged and is replaced by scar tissue (fibrosis). When this happens, the bone marrow cannot function correctly, which Show Full Answer

Yes, polycythemia vera (PV) can progress to myelofibrosis (MF). About 25% of people with PV develop myelofibrosis within 20 years of their initial diagnosis.

In this progression, the bone marrow becomes damaged and is replaced by scar tissue (fibrosis). When this happens, the bone marrow cannot function correctly, which affects proper blood cell development. While early stages of myelofibrosis may not show symptoms, it's important to know that this progression represents a more serious development of the condition. When MF develops from PV, it's considered secondary myelofibrosis rather than primary myelofibrosis. This transformation can lead to bone marrow failure.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Polycythemia Vera: Causes, Symptoms, and Treatments

How Polycythemia Vera Can Transform Into Myelofibrosis