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What causes ischemic changes in small blood vessels in the brain with myeloproliferative neoplasms?

In MPNs like polycythemia vera (PV) and essential thrombocythemia (ET), ischemic changes in small brain vessels can occur due to the way these conditions affect your blood.

Here's what happens:

- Too many red blood cells Show Full Answer

What causes ischemic changes in small blood vessels in the brain with myeloproliferative neoplasms?

In MPNs like polycythemia vera (PV) and essential thrombocythemia (ET), ischemic changes in small brain vessels can occur due to the way these conditions affect your blood.

Here's what happens:

- Too many red blood cells (in PV) thicken your blood, reducing blood flow through tiny capillaries
- Elevated platelet counts (in both PV and ET) can cause blockages in small vessels
- These circulation issues can compromise blood flow to the brain

Common symptoms from these small vessel changes include:

- Headaches
- Dizziness
- Blurred vision or vision changes
- Ringing in the ears (tinnitus)
- Numbness and tingling
- A feeling of fullness in the head

The good news is that managing your MPN through treatments like phlebotomy (to reduce red blood cell counts) and low-dose aspirin can help restore normal blood flow and potentially reduce these symptoms. Many of these microvascular symptoms can improve with proper MPN treatment.

If you're experiencing these symptoms, it's important to discuss them with your hematologist so they can adjust your treatment plan accordingly.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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