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Real members of myMPNteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myMPNteam Member asked a question 💭
Roswell, NM
December 2, 2025
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Can polycythemia vera (PV) cause nausea?

Yes, PV can cause nausea at times. This typically happens when your spleen or liver becomes enlarged, which is common in PV. An enlarged spleen or liver can lead to:

* Abdominal fullness and bloating
* Loss of appetite
* Nausea
* Vomiting

About 75 percent of people with PV Show Full Answer

Can polycythemia vera (PV) cause nausea?

Yes, PV can cause nausea at times. This typically happens when your spleen or liver becomes enlarged, which is common in PV. An enlarged spleen or liver can lead to:

* Abdominal fullness and bloating
* Loss of appetite
* Nausea
* Vomiting

About 75 percent of people with PV experience an enlarged spleen. The pressure from these enlarged organs in your abdomen can trigger feelings of nausea and discomfort.

If you're experiencing persistent nausea, it's worth discussing with your doctor. They can evaluate whether it's related to organ enlargement or potentially another aspect of your PV, and help you find ways to manage this symptom.

December 2, 2025

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