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A myMPNteam Member asked a question 💭
Ellington, CT
December 10, 2025
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Answer Summary

Members discussed how polycythemia vera fatigue often strikes upon waking or in the afternoon, with many finding that stress, dehydration,... Read more

Members discussed how polycythemia vera fatigue often strikes upon waking or in the afternoon, with many finding that stress, dehydration, lack of exercise, and low iron levels can all worsen exhaustion. Several members shared that regular physical activity like cycling, walking, and home workouts, along with staying hydrated and managing everyday stress with more self-compassion, helped reduce their fatigue significantly. A recurring theme was that treatments like Besremi and Jakafi, combined with normalized iron levels, can restore energy enough to eliminate the need for afternoon naps.

A myMPNteam Member

I have to agree with JohnG about stress and fatigue. I don’t have the reserves anymore to handle stress, even everyday stressors. Having PV is really making me look at the stresses in my life and handling it better. I give my self a lot more grace than I have in the past.

December 13, 2025
A myMPNteam Member

A quick add on…I’ve noticed if I experience one of life’s everyday stress situations the day or night prior, I’ ll ‘usually ‘ have an increased dose of PV Fatigue the next day.

December 12, 2025
A myMPNteam Member

Hi, My PV fatigue has increased significantly in the last couple of months.. perhaps 3-4 weekly ‘ bouts’ . The main onset is upon waking, but afternoon-ish I can crash… Additional Sleep and or a nap is the cure… I’m a cyclist, but stopped when the weather turned cold… I ride the Rail Trails.

I also know I’m lax in staying hydrated in the same time period. I wonder if lack of cycling, lack of exercise and proper hydration could be the fatigue culprit ?? I have several pieces of nice home exercise equipment which I used last season. I know I feel very stiff and sore not moving like I used to…. I’ve started my home exercise routine ( which I really enjoy this week… ) I’ll report back on my PV fatigue John

December 11, 2025
A myMPNteam Member

They are beautiful ,This is my girl. I rescued her

December 16, 2025
A myMPNteam Member

😊🚴… Pets can be of great benefit if a persons situation and desire is there. My two Ragdolls are a huge boost.

December 15, 2025

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