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What are the risks that essential thrombocythemia (ET) with a CALR mutation will progress to myelofibrosis (MF)?

While specific progression rates for CALR-mutated ET aren't detailed in the available information, it's known that ET can progress to MF over time. The general risk factors that make transformation more likely Show Full Answer

What are the risks that essential thrombocythemia (ET) with a CALR mutation will progress to myelofibrosis (MF)?

While specific progression rates for CALR-mutated ET aren't detailed in the available information, it's known that ET can progress to MF over time. The general risk factors that make transformation more likely for people with ET include:

* Advanced age
* Severe thrombocytosis (very high platelet count)
* Leukocytosis (high white blood cell levels)
* Anemia
* Changes in the EZH2 or TP53 genes

Research suggests that people with triple-negative MPNs (those without JAK2, CALR, or MPL mutations) may have less severe symptoms and slower disease progression. However, this doesn't directly tell us about CALR-positive cases specifically.

It's important to work closely with your hematologist, who can monitor your condition regularly through blood tests and watch for any signs of progression. They'll look for changes in your blood counts and symptoms that might indicate transformation to MF.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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