Powered By
When I look back I believe it was using bleach in bathroom products to clean my house. In the old days we had household products that contained lots of chemicals. The fumes were so bad I had to open windows and wait for hrs to rinse it out! I was very ignorant of the chemicals in cleaning products!
Answer Summary
Members explored what may have caused their MPNs, sharing personal histories that included exposure to formaldehyde, benzene, roundup,... Read more
I was diagnosed really young at 22 years old (24 now). My hematologist says that I probably developed it either in the womb or as a baby. But I grew up in a basement with radon, so I can’t help but wonder if that could’ve caused my mutation, or possibly some kind of exposure during college. I lived with my best friend in college, and we were both diagnosed with blood cancers a few years after graduation (she had lymphoma, in remission now!). Such a weird coincidence.
I worked in a pathology lab in high school, breathed in formaldehyde vapors in an unventilated room 8 hours per month; smoked x12 years; had breast cancer with mastectomy and treatment x5 years; developed PV at age 83; and still alive and kicking at 90. I just say that there is no rhyme nor reason except that maybe God has another Machu Picchu for me to climb yet.
@A myMPNteam Member
What you present there does not correspond to reality. The vaccine from AstraZeneca was not an mRNA vaccine, as you imply, it was a traditional type of vaccine using a viral vector. Nothing to do with mRNA, as you speculate.
One should inform themselves thoroughly before pushing wild speculations.
https://www.bbc.com/news/health-59418123
The very rare side-effects related to that particular vaccine were mostly due the interaction between the adenovirus used as vector and a particular protein in the blood.
Absolutely nothing to do with your MPN mutation, which very likely you acquired very early on in life.
There are enough studies that showed, repeatedly, that the somatic mutations that cause MPNs are acquired early on in life, in utero and in the first years of life. Sometimes the accumulation of mutated cells is slow, sometimes it is faster. There are many factors that can contribute to this, including chance and age. MPNs have existed since humans exist, nothing to do with vaccines.
https://www.mpnallianceaustralia.org.au/adult-b...
https://ashpublications.org/thehematologist/art...
One should not conflate coincidences with causality, as MPNs take decades to develop.
Just because an acute health issue caused by a very specific factor involves platelets does not mean that a chronic disease, that is genetic and takes decades to manifest, being diagnosed around a vaccine or another, has the same cause as the acute issue. Many things involve platelets and have nothing to do with MPNs.
I think it's like why do only some smokers get COPD and/or lung cancer while many do not? There is so much that is not known about our bodies and disease. MPNs are rare so not enough is known and like Steve said, there are probably multiple reasons. I'm always kind of amazed our bodies work at all 😏 The body is so complicated and processes work within such narrow parameters. 🙂
I am part of a Familial MPN cluster. My daughter and I both have the JAK2 mutation that has caused a MPN. We both have the JAK2 46/1 (GGCC) MPN predisposing haplotype, which is an inherited predisposition to acquiring the JAK2 mutation. It is now known that many p[eoiple with the JAK2 mutation develop it in early childhood, sometime in utero. It then can take decades for the MPN to manifest. Some people carry the JAK2 mutation without developing a MPN, a condition known as Clonal Hematopoiesis of Indeterminate Potential (CHIP). It is known for sure what triggers the manifestation of a MPN for someone already carrying the JAK2 mutation. Exposure to environmental carcinogens is one of the very plausible theories. Evidence for this is found in the Pennsylvania PV cluster.
The full answer will likely be that MPNs are multidetermined. More than one factor is in play in developing the driver mutation and then in it manifesting as a MPN. We need more research intot he underlying causes to be sure.
Join
Your Privacy Choices
