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I’m interested to know what part inflammation has to play in symptoms of ET. Can this inflammation be controlled?

A myMPNteam Member asked a question 💭
Fort Gratiot, MI
September 13
 · 
Reactions
A myMPNteam Member

Here is the short answer. There are many scientific papers written on it.
Essential thrombocythemia (ET) causes chronic inflammation because the underlying JAK2 gene mutations hyperactivate blood-producing cells to release high levels of inflammatory signaling proteins called cytokines.
I have felt significantly better since following an anti inflammatory diet.
Hope you feel better. I follow my symptoms and just glance at my numbers.

September 13
A myMPNteam Member

Well worth trying both Green Tea and Curcumin, excellent anti-inflammatories. Green tea in particular is known to actively reduce CRP markers.

September 16
A myMPNteam Member

Plus I really like green tea in the form of iced tea!

September 18
myMPNteam

Inflammation plays a meaningful role in ET symptoms. The abnormal platelet activity that comes with ET can trigger inflammatory responses in blood vessels, contributing to symptoms like:

- Headaches
- Burning or tingling in the hands and feet
- Dizziness and lightheadedness
- Blurred vision

This inflammation can also increase Show Full Answer

Inflammation plays a meaningful role in ET symptoms. The abnormal platelet activity that comes with ET can trigger inflammatory responses in blood vessels, contributing to symptoms like:

- Headaches
- Burning or tingling in the hands and feet
- Dizziness and lightheadedness
- Blurred vision

This inflammation can also increase the risk of blood clots forming, which is one of the most serious concerns with ET. The good news is that inflammation-related symptoms can often be managed. There are several approaches that may help:

- Low-dose aspirin is commonly used to reduce platelet activity, which in turn helps lower inflammation and the risk of clotting
- Hydroxyurea can reduce abnormal blood counts, which may ease inflammatory symptoms
- Jakafi (Ruxolitinib), a JAK inhibitor, has shown success in managing symptoms driven by inflammation, though it's generally not the first treatment tried
- Antihistamines like Claritin or Zyrtec may help with inflammation-related itching

It's really important to work closely with a hematologist to find the right approach for your specific situation, as treatments are tailored based on age, risk level, and overall health.

September 13
A myMPNteam Member

Works for everyone including those without an MPN

September 17

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