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Real members of myMPNteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Any females on HRT with ET?

A myMPNteam Member asked a question 💭
February 19
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A myMPNteam Member

I don’t have my JAK2 results yet 🤬. It’s been over 4 weeks. I’m going to continue getting my pellets until I hear anything that says I shouldn’t. Funny how menopause and ET symptoms are similar. My HRT has been a game changer and improved my quality of life.

March 3
A myMPNteam Member

I think estrogen can increase the risk of blood clots?. Maybe HRT contains less estrogen than typical birth control pills? Do you have the jak2 mutation? Having the jak2 mutation increases the risk of blood clots vs calr or negative. This a good question because there has been a change in view about HRT and it will most likely be prescribed more often. I'm not a candidate. I had multiple scattered bilateral pulmonary emboli after six months on birth control.

March 3
A myMPNteam Member

I am on HRT & have ET. Only newly diagnosed. My haematologist didn’t seem concerned just warned about blood clots & have put me on aspirin. I will have to ask if I need to come off it?

March 3
myMPNteam

How does hormone replacement therapy affect females with essential thrombocythemia?

Hormone replacement therapy (HRT) can be a concern for women with essential thrombocythemia because ET already increases the risk of blood clots. Since HRT can also raise clotting risk, combining the two requires careful consideration with Show Full Answer

How does hormone replacement therapy affect females with essential thrombocythemia?

Hormone replacement therapy (HRT) can be a concern for women with essential thrombocythemia because ET already increases the risk of blood clots. Since HRT can also raise clotting risk, combining the two requires careful consideration with your healthcare team.

Women with ET who are at high risk for blood clots need special attention to treatment. The main goals are reducing platelet counts and preventing dangerous clots that could lead to heart attack, stroke, or deep vein thrombosis.

For women of childbearing age or those who are pregnant and at high risk for thrombosis, interferon alfa is typically the preferred treatment option. This immunotherapy drug is specifically mentioned as suitable for this population because it's safer during pregnancy and for younger women.

If you're considering or currently on HRT, it's important to discuss your individual risk factors with your doctor, including:

- Your age (women 60 and older have higher risk)
- History of blood clots or bleeding
- Platelet counts
- Presence of JAK2 mutation
- History of smoking or high blood pressure

Your treatment plan may include low-dose aspirin as a blood thinner, or medications like hydroxyurea to reduce platelet formation, depending on your specific risk category.

February 19

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