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Real members of myMPNteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myMPNteam Member asked a question 💭
Hamilton, OH
May 11
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A myMPNteam Member

It is correct that dosage varies according to individual needs. I have been on Hydroxyurea 25 of the past 26 years and have never received or needed a blood transfusion. I also don’t believe that has been commonly reported here by other users.

May 12
A myMPNteam Member

I’m on 500 mg twice a day M-F and 500 mg once a day on Sat and Sun. I think some are 1000 mg a day. And some are on less. It seems to vary quite a bit.

May 11
myMPNteam

The right dose of hydroxyurea really depends on the individual — their specific MPN type, blood counts, overall health, and how well they're tolerating the medication. There isn't a one-size-fits-all answer here.

What's important to know is that for MPNs, hydroxyurea is typically used at lower doses compared to other Show Full Answer

The right dose of hydroxyurea really depends on the individual — their specific MPN type, blood counts, overall health, and how well they're tolerating the medication. There isn't a one-size-fits-all answer here.

What's important to know is that for MPNs, hydroxyurea is typically used at lower doses compared to other conditions it treats. Your hematologist or oncologist will determine the safest and most effective dose for you personally, and will adjust it based on how your body responds over time. Here are some key things to keep in mind while on hydroxyurea:

- Never adjust your dose on your own — always talk to your doctor first
- Regular blood tests are essential to monitor your blood cell levels
- Watch for side effects like nausea, fatigue, mouth sores, or skin changes
- Avoid sun exposure and use strong sunscreen, as hydroxyurea can increase skin cancer risk

If you feel your current dose isn't working well or is causing side effects, bring that up with your care team. They can explore adjustments or alternative treatments.

May 11

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