Great question! CALR mutations are found in a notable portion of MPN cases, particularly in essential thrombocythemia (ET) and primary myelofibrosis (PMF). Clinical trials are actively exploring new treatments that target these genetic mutations.
Here are some helpful ways to find relevant clinical trials:
- Show Full Answer
Great question! CALR mutations are found in a notable portion of MPN cases, particularly in essential thrombocythemia (ET) and primary myelofibrosis (PMF). Clinical trials are actively exploring new treatments that target these genetic mutations.
Here are some helpful ways to find relevant clinical trials:
- clinicaltrials.gov — The FDA's database where you can search specifically for MPN trials involving CALR mutations
- MPN Research Foundation — Offers an eligibility assessment tool to help match you with trials
- MPN Cancer Connection — Lists ongoing trials in the U.S. and worldwide
When exploring trials, it helps to know the phase:
- Phase 1 — Focuses mainly on safety
- Phase 2 & 3 — Look at both safety and how well the treatment works Not all trials require taking a new medication either — some simply involve providing blood or bone marrow samples to help researchers better understand CALR and other mutations.
Speaking with an MPN specialist is a great first step, as they can help identify trials you may be eligible for based on your specific mutation and disease stage.
May 17
Join
Your Privacy Choices
